Purification Methods:
Crystallize it three times from acetone and dry it supporting vacuum at ca 45o. Alternatively, keep it in contact with NaOH beads for 3 hours, with rare shaking, decant and fractionally distill it. It also recrystallizes from CH2Cl2 on an extension of pet ether.
Crystallize 2-Amino-6-methylpyridinethree times from acetone and dry it supporting vacuum at ca 45o. Alternatively, keep it in connection with NaOH pellets for 3 hours, with rare shaking, decant and fractionally distill it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallizes from CH2Cl2 on an extension of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Bilstein 22/9 V 210.] Uses of 2-Amino-6-Methylpyridine is Intermediate.
● 4-Chlorobenzaldehyde
● 2-Picoline Sodium
● Ferric nitrate
● Ammonia
● Purity(GC) min. 98.0 %
● Purity min. 98.0 %
● MP 42.0 to 45.0 deg-C
● Solubility in Water very low turbidity
Properties of 2-Amino-6-methylpyridine:
● Similar Categories Building Blocks, C6,
Chemical Synthesis,
Heterocyclic Building, Blocks, many more
● assay 98%
● Melting Point 40-44 °C (lit.)
● InChI Key QUXLCYFNVNNRBE-UHFFFAOYSA-N
● Boiling Point 208-209 °C(lit.)
● Density 1.0275 (estimate)
● refractive index 1.5560 (estimate)
● Flashpoint: 218 °F
● Storage temp. Store below +30°C.
● form Crystalline Low Melting Solid
● color Yellow
● Water Solubility very faint turbidity
● Sensitive Hygroscopic
● BRN 107048
● CAS DataBase Reference 1824-81-3(CAS DataBase Reference)
● NIST Chemistry Reference 2-Pyridinamine, 6-methyl-(1824-81-3)
● EPA Substance Registry System 2-Pyridinamine, 6-methyl-(1824-81-3)
Safety Information:
● Signal word Danger
● Hazard reports H301-H310-H315-H319-H335
● Special Protective Devices Eyeshields, Face Shields, Gloves,
type P2 (EN 143) respirator cartridges.
● Flash Point(C) 103 °C
● Flash Point(F) 217.4 °F
● RIDADR UN 2811 6.1 / PGIII
Hazard Statements:
● Code Hazard statements Hazard class
● H301 Toxic if swallowed Acute, toxicity, oral
● H310 Fatal in touch with skin Acute toxicity, dermal
● H315 Causes skin irritation Skin corrosion/irritation
● H319 Causes severe eye irritation Serious eye damage/eye irritation
● H335 May cause respiratory irritation Specific target organ toxicity, single exposure;
Respiratory tract irritation
Precautionary Statements:
● P261 Prevents breathing dust/fume/gas/mist/vapours/spray.
● P262 Do not put in eyes, on the skin, Or in your clothes.
● P264 Wash hands if you touch it for any purpose.
● P264 Wash skin nicely after handling.
● P270 Avoid eating, drinking or smoke when using this chemical.
● P280 Wear protective gloves/clothing and also eyes, face.
● P310 Quickly call a POISON CENTER or doctor/physician.
● P301+P310 IF swallowed: Instantly call a poison center or doctor/physician.
● P302+P350 IF ON SKIN: Kindly wash with an excess of soap and water.
● P307+P311 IF flashed: call a POISON CENTER or doctor/physician.
● P405 Store secured up.
● P501 Dispose of contents
7-Azaindole:
Chemical Properties:
Brown-Crystalline Solid.
Uses: Imidazolinone derivatives as CGRP receptor antagonists used in the treatment
Purification Methods:
Recrystallize 7-Azaindole regularly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the pirate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]
7-Azaindole Properties:
● Melting point: 105-107 °C(lit.)
● Boiling point: 270 °C (753.1004 mmHg)
● Density 1.1151 (rough estimate)
● refractive index 1.5500 (estimate)
● Flashpoint: 270°C
● Storage temp. Refrigerator
● form Powder
● color White to off-white
● BRN 109667
● InChIKey MVXVYAKCVDQRLW-UHFFFAOYSA-N
● CAS DataBase Reference 271-63-6(CAS DataBase Reference)
● NIST Chemistry Reference 1H-Pyrrolo[2,3-b]pyridine(271-63-6)
- EPA Substance Registry System 1H-Pyrrolo[2,3-b] pyridine(271-63-6)