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What Is 2-Amino-6-Methylpyridine?

Purification Methods:

Crystallize it three times from acetone and dry it supporting vacuum at ca 45o. Alternatively, keep it in contact with NaOH beads for 3 hours, with rare shaking, decant and fractionally distill it. It also recrystallizes from CH2Cl2 on an extension of pet ether.

 

Crystallize 2-Amino-6-methylpyridine three times from acetone and dry it supporting vacuum at ca 45o. Alternatively, keep it in connection with NaOH pellets for 3 hours, with rare shaking, decant and fractionally distill it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallizes from CH2Cl2 on an extension of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Bilstein 22/9 V 210.] Uses of 2-Amino-6-Methylpyridine is Intermediate.

Raw materials:
     4-Chlorobenzaldehyde
     2-Picoline Sodium
     Ferric nitrate
     Ammonia

Specification:
     Purity(GC)         min. 98.0 %
     Purity                 min. 98.0 %
     MP                           42.0 to 45.0 deg-C
     Solubility in Water    very low turbidity

Properties of 2-Amino-6-methylpyridine: 

     Similar Categories                       Building Blocks, C6,
                                                    Chemical Synthesis, 
                                                    Heterocyclic Building, Blocks, many more
     assay                                           98%
     Melting Point                                40-44 °C (lit.)
     InChI Key                                     QUXLCYFNVNNRBE-UHFFFAOYSA-N
     Boiling Point                                 208-209 °C(lit.)
     Density                                         1.0275 (estimate)
     refractive index                            1.5560 (estimate)
     Flashpoint:                                    218 °F
     Storage temp.                               Store below +30°C.
     form                                              Crystalline Low Melting Solid
     color                                              Yellow
     Water Solubility                             very faint turbidity
     Sensitive                                       Hygroscopic
     BRN                                              107048
     CAS DataBase Reference            1824-81-3(CAS DataBase Reference)
     NIST Chemistry Reference           2-Pyridinamine, 6-methyl-(1824-81-3)
     EPA Substance Registry System  2-Pyridinamine, 6-methyl-(1824-81-3)                                          

Safety Information:


     Signal word                                               Danger
     Hazard reports                                          H301-H310-H315-H319-H335
     Special Protective Devices                       Eyeshields,  Face Shields,  Gloves,
                                                                              type P2 (EN 143) respirator cartridges.
     Flash Point(C)                                           103 °C
     Flash Point(F)                                            217.4 °F
     RIDADR                                                     UN 2811 6.1 / PGIII                                     

Hazard Statements: 

     Code    Hazard statements                             Hazard class
     H301    Toxic if swallowed                              Acute, toxicity, oral
     H310    Fatal in touch with skin                      Acute toxicity, dermal
     H315    Causes skin irritation                         Skin corrosion/irritation
     H319    Causes severe eye irritation              Serious eye damage/eye irritation
     H335 May cause respiratory irritation         Specific target organ toxicity, single exposure;
                                                                                Respiratory tract irritation

Precautionary Statements: 

     P261                            Prevents breathing dust/fume/gas/mist/vapours/spray.
     P262                             Do not put in eyes, on the skin, Or in your clothes.
     P264                             Wash hands if you touch it for any purpose.
     P264                             Wash skin nicely after handling.
     P270                             Avoid eating, drinking or smoke when using this chemical.
     P280                             Wear protective gloves/clothing and also eyes, face.
     P310                             Quickly call a POISON CENTER or doctor/physician.
     P301+P310                   IF swallowed: Instantly call a poison center or doctor/physician.
     P302+P350                   IF ON SKIN: Kindly wash with an excess of soap and water.
     P307+P311                   IF flashed: call a POISON CENTER or doctor/physician.
     P405                             Store secured up.
     P501                             Dispose of contents

7-Azaindole:

Chemical Properties:

Brown-Crystalline Solid.

Uses: Imidazolinone derivatives as CGRP receptor antagonists used in the treatment

Purification Methods:

Recrystallize 7-Azaindole regularly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the pirate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]

7-Azaindole Properties: 

     Melting point:                          105-107 °C(lit.)
     Boiling point:                           270 °C (753.1004 mmHg)
     Density                                    1.1151 (rough estimate)
     refractive index                        1.5500 (estimate)
     Flashpoint:                                270°C
     Storage temp.                            Refrigerator
     form                                            Powder
     color                                            White to off-white
     BRN                                             109667
     InChIKey                                       MVXVYAKCVDQRLW-UHFFFAOYSA-N
     CAS DataBase Reference            271-63-6(CAS DataBase Reference)
     NIST Chemistry Reference          1H-Pyrrolo[2,3-b]pyridine(271-63-6)

  • EPA Substance Registry               System 1H-Pyrrolo[2,3-b] pyridine(271-63-6)

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